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KMID : 0613820040140020356
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Journal of Life Science
2004 Volume.14 No. 2 p.356 ~ p.361
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The Effect of Porphyra tenera Extract on Serum Lipid Content in Ovariectomized Rats
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Han Hee-Sun
Bae Song-Ja
Kim Mi-Hyang
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Abstract
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The aim of this study is to evaluate the effect of Porphyra tenera (PT) extract on serum lipids content in ovariectomized rats. From day 3 until 42 after the ovariectomy, Sprague-Dawley female rats were randomly assigned to the following groups : sham-operated rats (Sham), ovariectomized control rats (OVX-control), ovariectomized rats supplemented with PT at 50 mg/kg bw/day (OVX-PT50), 200 mg/kg bw/day (OVX- PT200). The PT ethanol extract were orally administrated at 1 ml per day. Body weight gain, food intake and food efficiency ratio were not significantly different between groups. Although total- cholesterol was increased in OVX-control, supplementation with the PT decreased the level of cholesterol in serum. Especially, it was significantly decreased in OVX-PT50 (p<0.05). Triglyceride was significantly decreased to almost all of groups supplemented with PT (p<0.05). The levels of HDL- cholesterol was higher in PT extract group than OVX-control. These results suggest that supplementation with the PT extract positively influenced on lipid concentration in serum. Consequently, we expect that PT extract decrease risk of cardiovascular diseases by postmenopausal.
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KEYWORD
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Porphyra tenera, ovariectomized rat, serum lipids
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